Antifungal potential, mechanism of action, and toxicity of 1,4-naphthoquinone derivatives
The findings indicate that primary antifungal mechanism of 2,3-DBNQ might involve disrupting fungal membrane permeability, which leads to increased nucleotide leakage. This insight underscores the need for further research to enhance the selectivity and safety of naphthoquinones for potential therapeutic applications.
Authors
- Ana Cláudia Alves Cortez (ORCID: https://orcid.org/0000-0002-0425-8661)
- Naira Sulany Oliveira de Sousa (ORCID: https://orcid.org/0000-0002-9344-1192)
- Raissa Sayumy Kataki Fonseca (ORCID: https://orcid.org/0000-0001-7628-9195)
- João Vicente Braga de Souza (ORCID: https://orcid.org/0000-0002-3163-7499)
- Juan Diego Ribeiro de Almeida (ORCID: https://orcid.org/0000-0002-9630-0029)
- Émerson Silva Lima (ORCID: https://orcid.org/0000-0002-9367-2812)
- Juliana Gomes de Souza Oliveira
- Hagen Frickmann (ORCID: https://orcid.org/0000-0002-8967-9528)
- Érica Simplício de Souza (ORCID: https://orcid.org/0000-0002-2389-4401)
Institutions
- Instituto Nacional de Pesquisas da Amazônia (BR)
- Bundeswehrkrankenhaus (DE)
- Universidade do Estado do Amazonas (BR)
- Universidade Federal do Amazonas (BR)
Publication Details
- Journal
- European Journal of Microbiology and Immunology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1556/1886.2024.00072
- Citations
- 5
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação de Amparo à Pesquisa do Estado do Amazonas