Association and causal impact of TERT genetic variants on peripheral blood leukocyte telomere length and cerebral small vessel disease risk in a Chinese Han population: a mendelian randomization analysis
Multiple genetic models and MR results indicate that TERT gene SNPs may be related to an elevated risk of CSVD, and that shorter LTL may be causally linked to such CSVD risk.
Authors
- Jiuhan Zhao (ORCID: https://orcid.org/0000-0002-5248-6634)
- Wanru Geng (ORCID: https://orcid.org/0000-0001-7088-4938)
- Ying Song (ORCID: https://orcid.org/0000-0002-5426-9916)
- Long Yin
- Jialiang Xu (ORCID: https://orcid.org/0000-0001-8378-416X)
- Jialu Wang
Institutions
- First Affiliated Hospital of Liaoning Medical University (CN)
- Liaoning Provincial People's Hospital (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1186/s13023-024-03316-5
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shenyang Science and Technology Bureau