Blocking TSP1 Ameliorates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting the TGF-β/SMAD Pathway
TSP1 expression is increased in the CC of DMED rats. HG-induced TSP1 secretion via autocrine signaling from CCSMCs and/or paracrine signaling from CCFs to accelerate penile fibrosis. LSKL, an antagonist of TSP1, could improve erectile dysfunction by inhibiting the TGF-β/SMAD pathway.
Authors
- Zhongcheng Xin (ORCID: https://orcid.org/0000-0002-0361-2737)
- Tiegui Nan (ORCID: https://orcid.org/0000-0003-1325-6382)
- Xiao-Hui Tan (ORCID: https://orcid.org/0000-0003-4139-8716)
- Ruili Guan (ORCID: https://orcid.org/0000-0003-0422-846X)
- Pengchao Gao (ORCID: https://orcid.org/0009-0001-9650-0901)
- Mancheng Xia (ORCID: https://orcid.org/0000-0002-9209-7246)
- Dong Fang (ORCID: https://orcid.org/0000-0001-6746-6559)
- Yiming Yuan (ORCID: https://orcid.org/0000-0002-8312-0723)
- Xinfei Li (ORCID: https://orcid.org/0000-0002-4201-2443)
- Zhuo Zhou
- Xuesong Li (ORCID: https://orcid.org/0000-0002-7030-0856)
- Fangzhou Zhao (ORCID: https://orcid.org/0000-0001-8109-8916)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Beijing Chest Hospital (CN)
- Peking University First Hospital (CN)
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- The World Journal of Men s Health
- Published
- 2024-08-23
- DOI
- https://doi.org/10.5534/wjmh.240065
- Citations
- 3
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality