The tumor immune microenvironment in resected treatment-naive pancreatic cancer patients with long-term survival
In this study, we delved into the TIME with metatranscriptomics and IF staining analyses to understand the prerequisite of prolonged survival in PDAC patients. In LTS, several biological pathways were overexpressed, and specific microbiomes were identified. Furthermore, apparent differences in driven immune factors were found that provide valuable insights into developing new treatment strategies.
Authors
- Casper W.F. van Eijck (ORCID: https://orcid.org/0000-0002-1461-6725)
- Casper H.J. van Eijck (ORCID: https://orcid.org/0000-0002-9511-2157)
- Karishma Lila
- Lara R. Heij (ORCID: https://orcid.org/0000-0002-0602-3356)
- Bas Groot Koerkamp (ORCID: https://orcid.org/0000-0003-1917-6973)
- Lola Alonso (ORCID: https://orcid.org/0000-0002-3493-718X)
- Núria Malats (ORCID: https://orcid.org/0000-0003-2538-3784)
- Eveline E. Vietsch (ORCID: https://orcid.org/0000-0003-0631-4484)
- Georg Wiltberger (ORCID: https://orcid.org/0000-0003-2384-3847)
- Maaike Verheij (ORCID: https://orcid.org/0000-0001-9686-3676)
- Jie Ju (ORCID: https://orcid.org/0009-0004-2532-3655)
- Yunlei Li (ORCID: https://orcid.org/0000-0002-5697-1602)
- Andrew Stubbs (ORCID: https://orcid.org/0000-0001-9817-9982)
- Michael Doukas
Institutions
- Erasmus MC (NL)
- Spanish National Cancer Research Centre (ES)
- Essen University Hospital (DE)
- Universitätsklinikum Aachen (DE)
- Erasmus MC Cancer Institute (NL)
- University of Duisburg-Essen (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Pancreatology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.pan.2024.08.014
- Citations
- 3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Hanarth Fonds