Production of physiological amounts of hemostatic proteins by human donor livers during ex situ long-term normothermic machine perfusion for up to 7 days
During long-term NMP of human livers, functionally active hemostatic proteins are released into the perfusate in substantial quantities, but some proteins appear to have decreased functional properties compared with proteins in normal human plasma. We propose that NMP may be used as a platform to test efficacy of drugs that stimulate or inhibit the production of coagulation factors or to test liver-mediated clearance of prohemostatic protein therapeutics.
Authors
- Bianca Lascaris (ORCID: https://orcid.org/0000-0003-0258-1112)
- Silke B. Bodewes (ORCID: https://orcid.org/0000-0001-6137-4901)
- Maarten W. Nijsten (ORCID: https://orcid.org/0000-0002-0981-9392)
- Vincent Erwin de Meijer (ORCID: https://orcid.org/0000-0002-7900-5917)
- Robert Jack Porte (ORCID: https://orcid.org/0000-0003-0538-734X)
- Jelle Adelmeijer (ORCID: https://orcid.org/0000-0003-3693-2750)
- Ton Lisman (ORCID: https://orcid.org/0000-0002-3503-7140)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.jtha.2024.08.004
- Citations
- 4
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Amsterdam University Medical Centers
- Universiteit van Amsterdam
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek