Engeletin attenuates the inflammatory response via inhibiting TLR4-NFκB signaling pathway in Crohn's disease-like colitis
ENG has been proven to alleviate inflammation and ameliorate the damage of epithelial barrier in CD-like colitis. ENG also suppressed the M1 macrophages polarization and the inhibited inflammatory cytokines. TLR4-NFκB signaling pathway, especially TLR4, may be the target of ENG. These data offer a new insight into the therapeutic mechanisms of ENG.
Authors
- Yuxuan Peng (ORCID: https://orcid.org/0000-0002-8448-4991)
- Ziyun Wei
- Chang Shu (ORCID: https://orcid.org/0000-0001-9102-0899)
- Jieyu Liu (ORCID: https://orcid.org/0000-0001-8550-7676)
- Xiao Ni (ORCID: https://orcid.org/0000-0002-8159-9275)
- He Cui
- Yunwei Li
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.jep.2024.118733
- Citations
- 14
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 7.70