Risks of Fetal Exposure to Topiramate

( N Engl J Med . 390(12):1141–1142. doi: 10.1056/NEJMe2401164) Antiseizure medications are frequently used in individuals of childbearing potential for a variety of conditions such as pain management, epilepsy, and psychiatric disorders. However, these medications pose potential risks to the developing fetus, including congenital malformations and cognitive or behavioral impairments. Although all antiseizure medications have teratogenic potential, the severity of these effects varies significantly across different medications.