Impact of Discontinuing Oxytocin in Active Labor on Neonatal Morbidity: An Open-Label, Multicenter, Randomized Trial
( Lancet . 2023;402(10417)2091–2100. doi: 10.1016/S0140-6736(23)01803-2) Oxytocin is a widely used drug worldwide, employed in either labor induction or labor augmentation. However, ambiguities persist regarding the ideal length of oxytocin delivery and its potential impact on neonatal and maternal outcomes. A previous clinical trial conducted in 2021 found a trivial rise in cesarean deliveries when oxytocin was discontinued, although this difference lacked both clinical and statistical significance. The current study sought to assess the effects of discontinuing oxytocin during the active phase of labor on neonatal morbidity and maternal complications.
Authors
- Paul Guerby (ORCID: https://orcid.org/0000-0002-2662-4351)
- Éric Boudier
- G Lévy
- Aude Girault (ORCID: https://orcid.org/0000-0002-6101-1200)
- Tiphaïne Raia-Barjat (ORCID: https://orcid.org/0000-0002-4408-6075)
- Camille Le Ray (ORCID: https://orcid.org/0000-0003-0891-1063)
- Gilles Kayem (ORCID: https://orcid.org/0000-0002-8218-8814)
- Diane Korb (ORCID: https://orcid.org/0000-0002-3074-8269)
- Jessica Rousseau
- Julie Carrara (ORCID: https://orcid.org/0000-0001-7064-6008)
- Paul Berveiller (ORCID: https://orcid.org/0000-0002-7814-6945)
- Charles Garabédian (ORCID: https://orcid.org/0000-0003-2105-9784)
- Mona Massoud (ORCID: https://orcid.org/0009-0004-4549-5059)
- Loı̈c Sentilhes (ORCID: https://orcid.org/0000-0003-0009-3625)
- Raoul Desbrière (ORCID: https://orcid.org/0000-0001-7783-1943)
- Éric Verspyck (ORCID: https://orcid.org/0000-0002-7827-5595)
- Hélène Heckenroth
- N. Winer
- Élie Azria (ORCID: https://orcid.org/0000-0002-6159-6253)
- Caroline Bohec
- Julie Blanc (ORCID: https://orcid.org/0000-0002-1542-504X)
- C. Bertholdt
- G Roth
Publication Details
- Journal
- Obstetric Anesthesia Digest
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1097/01.aoa.0001026588.44771.63
- Primary Topic
- Maternal and Perinatal Health Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00