Punica granatum L. leaf extract enhances stress tolerance and promotes healthy longevity through HLH-30/TFEB, DAF16/FOXO, and SKN1/NRF2 crosstalk in Caenorhabditis elegans
Our findings emphasize the potential of PGL extract to ameliorate age-related decline, induce longevity and further enhance healthspan. Given the diverse effects on the molecular network associated with stress-adaptations, longevity and metabolic control, PGL extract might become a promising natural product with a particular importance to the field of gerontology.
Authors
- Monika N. Todorova (ORCID: https://orcid.org/0009-0000-2892-7420)
- Milen I. Georgiev (ORCID: https://orcid.org/0000-0001-5248-6135)
- Liliya V. Mihaylova (ORCID: https://orcid.org/0000-0002-1690-1490)
- Martina S. Savova (ORCID: https://orcid.org/0000-0002-3852-8658)
Institutions
- Bulgarian Academy of Sciences (BG)
- Center of Plant Systems Biology and Biotechnology (BG)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.phymed.2024.155971
- Citations
- 12
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- European Commission
- Horizon 2020
- European Regional Development Fund