Non-invasive surrogate markers of pulmonary hypertension are associated with poor survival in patients with cancer
In this study, fewer patients with cancer had surrogate parameters for PH compared with previously published results among patients with lung cancer. Consequently, the prevalence of PH in other cancers might be lower compared with lung cancer; however, PH still has a negative impact on prognosis. Furthermore, our data does not provide evidence that lung metastases cause PH. Thus, our results support the idea that lung cancer-associated PH represents a new category of PH. Our results also highlight the importance of further studies in the field of cardio-oncology.
Authors
- Gerson Lüdecke
- Michael Cekay (ORCID: https://orcid.org/0009-0007-0090-0294)
- Ingolf Askevold (ORCID: https://orcid.org/0000-0002-3247-4863)
- Werner Seeger (ORCID: https://orcid.org/0000-0003-1946-0894)
- Marco Stein (ORCID: https://orcid.org/0000-0002-8292-6207)
- Bastian Eul
- Jochen Wilhelm (ORCID: https://orcid.org/0000-0001-5544-9647)
- Philipp Friedrich Arndt
- Rajkumar Savai (ORCID: https://orcid.org/0000-0003-1538-2091)
- Felix Alexander Zeppernick (ORCID: https://orcid.org/0000-0002-2909-9492)
- Natascha Sommer (ORCID: https://orcid.org/0000-0002-8915-7762)
- Christine Langer (ORCID: https://orcid.org/0000-0002-0357-2931)
- Fritz Roller (ORCID: https://orcid.org/0000-0002-6927-3248)
- Khodr Tello (ORCID: https://orcid.org/0000-0002-5557-623X)
- Friedrich Grimminger (ORCID: https://orcid.org/0000-0001-8725-6276)
- Ulf Sibelius
- Johanna K Franken
- Soni Savai Pullamsetti
Institutions
- Justus-Liebig-Universität Gießen (DE)
- Max Planck Institute for Heart and Lung Research (DE)
- German Center for Lung Research (DE)
- Universities of Giessen and Marburg Lung Center (DE)
- Cardio-Pulmonary Institute (DE)
Publication Details
- Journal
- BMJ Open Respiratory Research
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1136/bmjresp-2023-001916
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Max-Planck-Gesellschaft
- Deutsches Zentrum für Lungenforschung
- Cardio-Pulmonary Institute