Acetylcytidine modification of DDX41 and ZNF746 by N-acetyltransferase 10 contributes to chemoresistance of melanoma
Our study elucidates the previously unrecognized role of NAT10-mediated ac4C modification in the chemoresistance of melanoma and provides a rationale for developing new strategies to overcome chemoresistance in melanoma patients.
Authors
- Ying Zhang (ORCID: https://orcid.org/0000-0003-3074-9998)
- Zuohui Liang
- Shuangyan Xu (ORCID: https://orcid.org/0000-0001-9523-2266)
- Yun Zhu (ORCID: https://orcid.org/0000-0003-2691-6220)
- Yuefen Zeng
- Li Wang
Institutions
- Kunming Medical University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Sixth Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3389/fonc.2024.1448890
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China