Enhanced mitochondrial function in B cells from elderly type-2 diabetes mellitus patients supports intrinsic inflammation
In this paper, we measured B cell function in elderly healthy individuals (E<sub>H</sub>) and in elderly patients with Type-2 Diabetes Mellitus (T2DM, E<sub>T2DM</sub>), which are treatment-naive, as compared to healthy young (Y<sub>H</sub>) individuals. Results show a higher serum inflammatory status of elderly versus young individuals, and especially of E<sub>T2DM</sub> versus E<sub>H</sub>. This status is associated with a reduced response to the seasonal influenza vaccine and with increased frequencies of the circulating pro-inflammatory B cell subset called Double Negative (DN) B cells. B cells from E<sub>T2DM</sub> patients are not only more inflammatory but also hyper-metabolic as compared to those from E<sub>H</sub> controls. The results herein are to our knowledge the first to show that T2DM superimposed on aging further increases systemic and B cell intrinsic inflammation, as well as dysfunctional humoral immunity. Our findings confirm and extend our previously published findings showing that inflammatory B cells are metabolically supported.
Authors
- Valquíria Bueno (ORCID: https://orcid.org/0000-0001-8954-129X)
- Daniela Frasca (ORCID: https://orcid.org/0000-0002-9816-6679)
Institutions
- University of Miami (US)
- Sylvester Comprehensive Cancer Center (US)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Aging
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3389/fragi.2024.1444527
- Citations
- 1
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.38
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- National Institutes of Health