‘Risk-benefit’ assessment for comprehensive safety evaluation of Chinese patent medicines containing four common toxic ingredients: an analysis of clinical risk factors
1) There are four main types of Chinese patent medicines containing toxic ingredients. These include medicines with diester aconitine metabolites, mineral composition, Araceae metabolites, and hydrogen cyanide. 2) Digestive system, skin and its appendages, and allergic reactions were the main types of ADEs related to four types of Chinese patent medicines containing toxic ingredients. 3) There are four primary risk factors associated with the clinical use of Chinese patent medicines containing toxic ingredients: medicine, medication, individual and regulatory factors.
Authors
- Lin Li (ORCID: https://orcid.org/0000-0002-8264-0778)
- Huaqiang Zhai (ORCID: https://orcid.org/0000-0001-9652-9491)
- Yu Song (ORCID: https://orcid.org/0000-0003-4836-3954)
- Changming Zhong
- Namin Wei (ORCID: https://orcid.org/0000-0002-0586-3775)
- Nan Zhang (ORCID: https://orcid.org/0000-0002-8309-4262)
- Siyu Li (ORCID: https://orcid.org/0000-0002-2203-9294)
- Xiaoqing Wan (ORCID: https://orcid.org/0000-0001-9948-9173)
- Yongyan Wang (ORCID: https://orcid.org/0000-0002-5727-3451)
- Yanping Wang (ORCID: https://orcid.org/0000-0001-9395-1128)
- Guoxiu Liu (ORCID: https://orcid.org/0009-0008-7392-469X)
- Zhong‐Zhi Qian
- Wanlin Wu
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3389/fphar.2024.1324509
- Citations
- 2
- Primary Topic
- Plant-based Medicinal Research
- Type
- article
- Field-Weighted Citation Impact
- 0.93
Funders
- Beijing University of Chinese Medicine