Plasma level of alpha-synuclein oligomers as a biomarker for isolated rapid eye movement sleep behavior disorder diagnosis and progression: a prospective cohort study
Despite a potential role in the pathophysiology of iRBD, o-α-syn are not appropriate biomarkers for diagnosing or predicting disease progression. While this study offers insights into the pathogenesis of iRBD and neurodegenerative synucleinopathies, further large-scale longitudinal studies are warranted to validate these findings.
Authors
- Songnian Hu (ORCID: https://orcid.org/0000-0003-3966-3111)
- Ting Wang (ORCID: https://orcid.org/0000-0003-1169-0089)
- Lifang Zhao (ORCID: https://orcid.org/0000-0003-0884-8551)
- Hui Zhang (ORCID: https://orcid.org/0009-0008-1937-9387)
- Yuan Li (ORCID: https://orcid.org/0000-0001-6570-1527)
- Wei Mao (ORCID: https://orcid.org/0000-0003-1994-2770)
- Ying Chao (ORCID: https://orcid.org/0000-0001-7129-3435)
- Yanning Cai (ORCID: https://orcid.org/0000-0003-0879-9809)
Institutions
- Capital Medical University (CN)
- China Rehabilitation Research Center (CN)
- Beijing Geriatric Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3389/fneur.2024.1442173
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China