Design and evaluation of magnetic-targeted bilosomal gel for rheumatoid arthritis: flurbiprofen delivery using superparamagnetic iron oxide nanoparticles
This comprehensive investigation highlights the potential of FSB as a promising targeted drug delivery system for the effective management of osteoarthritis. The use of QbD and DOE in the formulation process, along with the integration of SPIONs, resulted in an optimized FSB formulation with enhanced entrapment efficiency and targeted delivery capabilities. The <i>in situ</i> forming hydrogel further supported the formulation's applicability for injectable applications, providing rapid gelation and sustained drug release. The <i>in vivo</i> results corroborate the formulation's efficacy, underscoring its potential for improving the treatment of osteoarthritis.
Authors
- Ahmad Salawi (ORCID: https://orcid.org/0000-0001-6342-284X)
- Sameer Alshehri (ORCID: https://orcid.org/0000-0003-2119-867X)
- Waleed Yousof Rizg (ORCID: https://orcid.org/0000-0002-3088-4084)
- Walaa A. Abualsunun (ORCID: https://orcid.org/0000-0003-4165-9728)
- Rana B. Bakhaidar (ORCID: https://orcid.org/0000-0002-8761-1538)
- Rayan Y. Mushtaq (ORCID: https://orcid.org/0000-0001-5317-1135)
- Majed Alghamdi (ORCID: https://orcid.org/0000-0003-0779-079X)
- Abdulmohsin J. Alamoudi (ORCID: https://orcid.org/0000-0002-9028-8225)
- Mallesh Kurakula (ORCID: https://orcid.org/0000-0002-8130-7068)
- Khaled M. Hosny (ORCID: https://orcid.org/0000-0002-4904-1378)
- N. Raghavendra Naveen (ORCID: https://orcid.org/0000-0002-8048-2438)
- Krishna Jayanth Rolla
- Humood Al Shmrany
Institutions
- Prince Sattam Bin Abdulaziz University (SA)
- Taif University (SA)
- King Abdulaziz University (SA)
- Thermo Fisher Scientific (United States) (US)
- Imam Abdulrahman Bin Faisal University (SA)
- Jazan University (SA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3389/fphar.2024.1433734
- Citations
- 5
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 2.35
Funders
- King Abdulaziz University