Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality
This study reveals the dual functions of IFN-I in anti-malarial immunity: Early IFN-α/β enhances immune responses against Plasmodium infection by promoting CD11a<sup>hi</sup>CD49d<sup>hi</sup>CD4<sup>+</sup> T cell, while late IFN-α/β suppresses these response by expanding PD-1<sup>+</sup>CD8<sup>+</sup> T cells. Moreover, both the SOCS1-related network motifs and TFs activation patterns contribute to determine distinct dynamics of IFN-I responses. Hence, our findings suggest therapies targeting SOCS1- or TFs-regulated IFN-I dynamics could be an efficacious approach for preventing malaria and enhancing vaccine efficacy.
Authors
- Zhiqiang Hu (ORCID: https://orcid.org/0000-0001-8854-3410)
- Xiao Yu (ORCID: https://orcid.org/0000-0003-2491-9110)
- Huadan Chen
- Yingchao Xie (ORCID: https://orcid.org/0009-0003-2163-7430)
- Jiansen Lu (ORCID: https://orcid.org/0000-0003-3875-5583)
- Xin‐zhuan Su (ORCID: https://orcid.org/0000-0003-3246-3248)
- Huaji Jiang (ORCID: https://orcid.org/0000-0003-0197-239X)
- Hongyu Li (ORCID: https://orcid.org/0000-0003-1784-4595)
- Jian Li (ORCID: https://orcid.org/0000-0002-7076-3332)
- Ke Zeng (ORCID: https://orcid.org/0000-0001-8876-6665)
- Chunmei Cai (ORCID: https://orcid.org/0000-0002-6984-4637)
- Zebin Wen (ORCID: https://orcid.org/0009-0007-1903-5034)
Institutions
- Qinghai University (CN)
- Xiamen University (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- National Institute of Allergy and Infectious Diseases (US)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.jare.2024.08.027
- Citations
- 3
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- National Institutes of Health
- Basic and Applied Basic Research Foundation of Guangdong Province
- National Institute of Allergy and Infectious Diseases
- NHLBI Division of Intramural Research