Nervonic acid triggered ovarian inflammation by inducing mitochondrial oxidative stress to activate NLRP3/ IL-1β pathway
Collectively, our current study suggests that NA is a typical metabolite of metabolic syndrome, which strongly influences the ovarian function and embryo survival and also provides that interfering with mitochondrial ROS production is a potential strong strategy for target solving abnormal NA accumulation.
Authors
- Xiangfang Zeng (ORCID: https://orcid.org/0000-0002-0245-989X)
- Bangxin Xue
- Xinyu Wang (ORCID: https://orcid.org/0000-0003-2151-9824)
- Quan Shuang
- Huanwen Wu (ORCID: https://orcid.org/0000-0002-3996-3176)
- Lu Liu (ORCID: https://orcid.org/0000-0002-7496-5564)
- Siyu Li (ORCID: https://orcid.org/0000-0002-3027-1800)
- Zhiwen Zhang (ORCID: https://orcid.org/0000-0002-0797-9448)
- Haitao Yu (ORCID: https://orcid.org/0000-0002-0302-998X)
- Shuang Cai
- Xiangzhou Zeng (ORCID: https://orcid.org/0000-0002-3371-9674)
- Xinyin Fan
- Shiyan Qiao
- Liangrui Zhou
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Feed Research Institute (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.jare.2024.08.028
- Citations
- 11
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- National Natural Science Foundation of China
- Beijing Municipal Education Commission