Synthesis of BODIPY FL-tethered ridaifen-B, RID-B-BODIPY, and its localization in cancer cells
We synthesized ridaifen-B boron dipyrromethene (<b>RID-B-BODIPY</b>) using 2-methyl-6-nitro benzoic anhydride (MNBA)-mediated dehydration condensation reaction between amino alkyl-tethered RID and BODIPY FL. Comparative experiments between dicyclohexylcarbodiimide (DCC) and MNBA for their coupling reactions demonstrated that MNBA is an effective condensation reagent for amines and BODIPY FL. A cell staining study with <b>RID-B-BODIPY</b> showed intracellular localization of BODIPY FL fluorescence, attributed to the <b>RID-B</b> structure, indicating the successful development of a tool for analyzing intracellular molecular behavior efficiently.
Authors
- Isamu Shiina
- Kaho Tsuchiya
- Shunsuke Takahashi (ORCID: https://orcid.org/0000-0003-0492-7906)
- Fumi Sato (ORCID: https://orcid.org/0000-0003-1616-9057)
- Yuta Semba
- Tomohiro Takano (ORCID: https://orcid.org/0000-0002-8167-9670)
- Eri Murata (ORCID: https://orcid.org/0009-0009-4458-7118)
- Takatsugu Murata (ORCID: https://orcid.org/0000-0002-3933-8928)
- Amane Yoneoka
- Chihiro Matsuda
- Yukitoshi Nagahara
- Kyoka Komukai
- Anju Sakai
Institutions
- Tokyo University of Science (JP)
- Tokyo Denki University (JP)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3389/fchem.2024.1451468
- Citations
- 4
- Primary Topic
- Luminescence and Fluorescent Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.47