Elucidating the mechanism of plasticizers inducing breast cancer through network toxicology and molecular docking analysis
The study provides evidence that exposure to plasticizers may influence breast cancer pathogenesis through interactions with critical proteins and signaling pathways. By employing network pharmacology, protein interactions, and molecular docking, our findings highlight the potential risks posed by plasticizers. These results underscore the need for further epidemiological and clinical research to fully understand the implications of plasticizer exposure on breast cancer risk, thus informing future preventive and therapeutic strategies.
Authors
- Chenning Zhang (ORCID: https://orcid.org/0000-0002-3372-3649)
- Na He (ORCID: https://orcid.org/0000-0001-5560-5312)
- Li Yin (ORCID: https://orcid.org/0000-0002-4566-8616)
- Ming-Yu Liu (ORCID: https://orcid.org/0000-0002-2239-8975)
Institutions
- Hainan Medical University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.ecoenv.2024.116866
- Citations
- 53
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 19.16