Gandouling Regulates Ferroptosis and Improves Neuroinflammation in Wilson’s Disease Through the LCN2/NLRP3 Signaling Pathway
GDL has anti-inflammatory and antioxidant effects. LCN2 is a differential gene associated with ferroptosis in WD. GDL may alleviate ferroptosis by inhibiting the LCN2/NLPR3 signaling pathway, thereby improving neuroinflammatory responses and exerting neuroprotective effects in WD.
Authors
- Yuya Wen
- Wenting Xie (ORCID: https://orcid.org/0000-0003-4387-7577)
- Chenling Zhao (ORCID: https://orcid.org/0000-0002-6894-787X)
- Jie Chen (ORCID: https://orcid.org/0000-0002-1568-8974)
- Liwei Tian (ORCID: https://orcid.org/0000-0002-4885-4908)
- Ting Dong (ORCID: https://orcid.org/0009-0000-7050-9820)
- Bojin Wu
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-08-01
- DOI
- https://doi.org/10.2147/jir.s465341
- Citations
- 11
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- Natural Science Foundation of Anhui Province