Knockdown of <scp>NFIL3</scp> modulates the <scp>AMPK</scp> pathway to suppress excessive cell proliferation, inflammation, and migration in rheumatoid arthritis
This study demonstrated that the inhibition of NFIL3 effectively controlled the AMPK/mTOR pathway, thereby suppressing the overactive proliferation, inflammation, and migration of fibroblast-like synoviocytes in human RA. This discovery implied that NFIL3 can be a serviceable biomarker for RA therapy.
Authors
- Fuyong Qiang (ORCID: https://orcid.org/0000-0003-0192-1963)
- Dan Xuan
- Jinghua Liu (ORCID: https://orcid.org/0000-0003-3195-3798)
- Jun Sheng (ORCID: https://orcid.org/0009-0005-7008-7097)
Institutions
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1111/1756-185x.15287
- Citations
- 2
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.47