Sex-Dependent Effects of Cardiometabolic Health and <i>APOE4</i> on Brain Age
This study indicates sex-dependent and time-dependent relationships between CMRs, <i>APOE4</i> status, and brain age. Our findings highlight the necessity of sex-stratified analyses to elucidate the role of CMRs in individual aging trajectories, providing a basis for developing personalized preventive interventions.
Authors
- Lars Tjelta Westlye (ORCID: https://orcid.org/0000-0001-8644-956X)
- Susana Muñoz Maniega (ORCID: https://orcid.org/0000-0001-5185-6384)
- James H. Cole (ORCID: https://orcid.org/0000-0003-1908-5588)
- Joanna Marguerite Wardlaw (ORCID: https://orcid.org/0000-0002-9812-6642)
- Josephine Barnes (ORCID: https://orcid.org/0000-0003-3178-025X)
- Maria del Carmen Valdés Hernández (ORCID: https://orcid.org/0000-0003-2771-6546)
- Mark E. Bastin (ORCID: https://orcid.org/0000-0002-0490-0845)
- David M. Cash (ORCID: https://orcid.org/0000-0001-7833-616X)
- Carole H. Sudre (ORCID: https://orcid.org/0000-0001-5753-428X)
- Jonathan M. Schott (ORCID: https://orcid.org/0000-0003-2059-024X)
- Tom C. Russ (ORCID: https://orcid.org/0000-0001-9797-2188)
- Marcus Richards (ORCID: https://orcid.org/0000-0001-9191-2192)
- William Coath (ORCID: https://orcid.org/0000-0002-3976-9461)
- Sarah‐Naomi James (ORCID: https://orcid.org/0000-0002-3800-4416)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Paul H. Redmond (ORCID: https://orcid.org/0000-0001-8272-8596)
- Sivaniya Subramaniapillai (ORCID: https://orcid.org/0000-0003-3207-0700)
- Simon R. Cox (ORCID: https://orcid.org/0000-0003-4036-3642)
- Louise S. Schindler
- Benjamin S. Aribisala (ORCID: https://orcid.org/0000-0002-6290-1707)
- Ann‐Marie G. de Lange (ORCID: https://orcid.org/0000-0002-5150-6656)
- Janie Corley (ORCID: https://orcid.org/0000-0002-7551-1871)
- J. R. Groves
Institutions
- University of Lausanne (CH)
Publication Details
- Journal
- Neurology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1212/wnl.0000000000209744
- Citations
- 12
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 4.82
Funders
- National Science Foundation
- Alzheimer's Association
- Brain Research UK
- Alzheimer's Society
- National Institute for Health and Care Research
- Age UK
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Norges Forskningsråd
- University College London Hospitals NHS Foundation Trust
- UK Dementia Research Institute
- National Institutes of Health
- California State University, Bakersfield
- Natural Sciences and Engineering Research Council of Canada
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Economic and Social Research Council
- Helse Sør-Øst RHF