Tumor immune microenvironment of NSCLC with EGFR exon 20 insertions may predict efficacy of first-line ICI-combined regimen
The immune microenvironment of EGFR ex20ins is more suppressive than that of L858R and wild-type, suggesting that ICI monotherapy may not be sufficient for these patients. ICI-combined regimen might be a treatment option for EGFR ex20ins due to tumor-promoting inflammation and noninferior T cell functions in the immune microenvironment.
Authors
- Ke-Jun Liu (ORCID: https://orcid.org/0000-0001-5770-7865)
- Kai‐Cheng Peng (ORCID: https://orcid.org/0000-0002-8094-9720)
- Xianwen Chen (ORCID: https://orcid.org/0000-0001-9262-2568)
- Qing Zhou (ORCID: https://orcid.org/0000-0002-1917-5105)
- Beibei Mao (ORCID: https://orcid.org/0000-0002-5889-4786)
- Quan-Quan Tan
- Longlong Gong (ORCID: https://orcid.org/0000-0002-5844-6078)
- Xue Zheng (ORCID: https://orcid.org/0000-0002-7091-0320)
- Yi-Long Wu (ORCID: https://orcid.org/0000-0002-3611-0258)
- Wendy Wu (ORCID: https://orcid.org/0000-0002-6169-5155)
- Tao Jiang (ORCID: https://orcid.org/0000-0002-7008-6351)
- Jun Jia (ORCID: https://orcid.org/0000-0001-7473-9092)
- Shiyuan Chen (ORCID: https://orcid.org/0000-0001-9805-2906)
- Zheng Zheng (ORCID: https://orcid.org/0000-0003-0421-9272)
- Hongrui Li (ORCID: https://orcid.org/0000-0002-2494-0262)
- Hongbo Zheng (ORCID: https://orcid.org/0000-0003-3836-2472)
- Jin-Ji Yang
- Hua-Jun Chen
- Xuchao Zhang
Institutions
- Wuhan University of Technology (CN)
- Dongguan People’s Hospital (CN)
- Berry Oncology (China) (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Genecast (China) (CN)
- Gaozhou People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Lung Cancer
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.lungcan.2024.107933
- Citations
- 8
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangdong Provincial People's Hospital