Next-generation lung cancer pathology: Development and validation of diagnostic and prognostic algorithms
Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors. In this study, we develop a clinically useful computational pathology platform for NSCLC that can be a foundation for multiple downstream applications and provide immediate value for patient care optimization and individualization. We train the primary multi-class tissue segmentation algorithm on a substantial, high-quality, manually annotated dataset of whole-slide images with lung adenocarcinoma and squamous cell carcinomas. We investigate two downstream applications. NSCLC subtyping algorithm is trained and validated using a large, multi-institutional (n = 6), multi-scanner (n = 5), international cohort of NSCLC cases (slides/patients 4,097/1,527). Moreover, we develop four AI-derived, fully explainable, quantitative, prognostic parameters (based on tertiary lymphoid structure and necrosis assessment) and validate them for different clinical endpoints. The computational platform enables the high-precision, quantitative analysis of H&E-stained slides. The developed prognostic parameters facilitate robust and independent risk stratification of patients with NSCLC.
Authors
- Mark Kühnel (ORCID: https://orcid.org/0000-0003-3558-2576)
- Reinhard Büttner (ORCID: https://orcid.org/0000-0001-8806-4786)
- Fabian Mairinger (ORCID: https://orcid.org/0000-0003-1067-0051)
- Sebastian Yves Friedrich Michels (ORCID: https://orcid.org/0000-0003-3164-870X)
- Junya Fukuoka (ORCID: https://orcid.org/0000-0002-2496-3050)
- Alexander Quaas (ORCID: https://orcid.org/0000-0002-3537-6011)
- Andrey Bychkov (ORCID: https://orcid.org/0000-0002-4203-5696)
- Wolfgang Hulla (ORCID: https://orcid.org/0000-0001-8189-4621)
- Yuri Tolkach (ORCID: https://orcid.org/0000-0001-5239-2841)
- Anne M. Schultheis
- Danny Jonigk (ORCID: https://orcid.org/0000-0002-5251-2281)
- Nadine Therese Gaisa (ORCID: https://orcid.org/0000-0002-4762-3964)
- Johannes Brägelmann (ORCID: https://orcid.org/0000-0002-1306-2169)
- Waleed Ahmad (ORCID: https://orcid.org/0000-0002-8174-4786)
- Yuan Wang (ORCID: https://orcid.org/0000-0003-2009-5572)
- Sebastian Klein
- Carina Kludt
- Franziska Klein
- Alexander Seper
- Alexey Pryalukhin
Institutions
- Danube Private University (AT)
- University of Cologne (DE)
- Fachhochschule Wiener Neustadt (AT)
- Düsseldorf University Hospital (DE)
- Kameda Medical Center (JP)
- Essen University Hospital (DE)
- Universitätsklinikum Aachen (DE)
- German Center for Lung Research (DE)
- University Hospital Cologne (DE)
- University Hospital Ulm (DE)
- Nagasaki University (JP)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Cell Reports Medicine
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.xcrm.2024.101697
- Citations
- 20
- Primary Topic
- AI in cancer detection
- Type
- article
- Field-Weighted Citation Impact
- 6.95