A magnetic‐directed micro‐particle with near‐<scp>IR</scp> light triggered guest‐release property
Abstract In this study, guest carriers, composed of magnetic‐directed hydrogel particles with near‐infrared (NIR)‐light‐triggered guest‐release properties, are prepared via the one‐pot method. The gel particles contain photostable NIR‐responsive polypyrrole nanoparticles with temperature‐sensitive poly(N‐isopropyl acrylamide), the combination of which can induce the accelerated release of encapsulated drugs by 337% upon 5 minutes of NIR light irradiation based on the release profile of NRMG‐1 at 10–15 min. Additionally, with magnetic iron oxide particles crosslinking the polyvinyl alcohol frames, these gel particles can form a physical barrier that decreases the release rate by 20% under an external magnetic field over 24 h. The magnetic iron oxide particles also enable the gel particles to reach their target destination without extra drug losses.
Authors
- Pengfei Cao (ORCID: https://orcid.org/0000-0003-2391-1838)
- Jin Ge (ORCID: https://orcid.org/0000-0003-2169-0218)
- Eugene B. Caldona (ORCID: https://orcid.org/0000-0002-5944-2263)
- Lihan Rong (ORCID: https://orcid.org/0000-0002-9351-059X)
- Rigoberto C. Advíncula (ORCID: https://orcid.org/0000-0002-2899-4778)
- Xiang Cheng (ORCID: https://orcid.org/0000-0002-3308-3506)
Institutions
- Oak Ridge National Laboratory (US)
- North Dakota State University (US)
- Case Western Reserve University (US)
- University of Tennessee at Knoxville (US)
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Journal of Applied Polymer Science
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1002/app.56110
- Citations
- 3
- Primary Topic
- Micro and Nano Robotics
- Type
- article
- Field-Weighted Citation Impact
- 0.93
Funders
- U.S. Department of Energy
- Office of Science
- Oak Ridge National Laboratory