Advancing toward precision migraine treatment: Predicting responses to preventive medications with machine learning models based on patient and migraine features
We developed an accurate prediction model for CGRP mAbs treatment response, leveraging detailed migraine features gathered from a headache questionnaire before starting treatment. Employing the same methods, the model performances for other medications were less impressive, though similar to the machine learning models reported in the literature for other diseases. This may be due to CGRP mAbs being migraine-specific. Incorporating medical comorbidities, genomic, and imaging factors might enhance the model performance. We demonstrated that migraine characteristics are important in predicting treatment responses and identified the most crucial predictors for each of the seven types of preventive medications. Our results suggest that precision migraine treatment is feasible.
Authors
- Narayan Kissoon (ORCID: https://orcid.org/0000-0002-6686-8537)
- Todd J. Schwedt (ORCID: https://orcid.org/0000-0002-7780-7086)
- Ann Murray (ORCID: https://orcid.org/0000-0002-4288-1841)
- Imon Banerjee (ORCID: https://orcid.org/0000-0002-3327-8004)
- Monique M. Montenegro (ORCID: https://orcid.org/0000-0002-6620-3308)
- Brandon Jones (ORCID: https://orcid.org/0000-0003-3693-5388)
- Chieh‐Ju Chao (ORCID: https://orcid.org/0000-0001-6155-0266)
- Han Wang (ORCID: https://orcid.org/0000-0001-7571-9536)
- Mark Whealy (ORCID: https://orcid.org/0000-0001-6414-6955)
- Gina Dumkrieger (ORCID: https://orcid.org/0000-0001-9519-5370)
- Chia‐Chun Chiang (ORCID: https://orcid.org/0000-0001-7802-7172)
- F. Michael Cutrer (ORCID: https://orcid.org/0000-0002-9869-3700)
- Yi‐Chieh Chen (ORCID: https://orcid.org/0000-0002-2132-5483)
- Liguo Wang (ORCID: https://orcid.org/0000-0003-2072-4826)
- Heather A. Ouellette
- Krista M. Burke
- Jennifer I. Stern
Institutions
- University of Minnesota (US)
- Mayo Clinic (US)
- WinnMed (US)
- Mayo Clinic Health System (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
- Arizona State University (US)
Publication Details
- Journal
- Headache The Journal of Head and Face Pain
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1111/head.14806
- Citations
- 25
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 9.64
Funders
- American Heart Association
- Amgen
- American Brain Foundation