Development of mutated β-catenin gene signature to identify CTNNB1 mutations from whole and spatial transcriptomic data in patients with HCC
As precision medicine for liver cancer treatment becomes a reality, diagnostic tools are needed to help classify patients into groups for the best treatment choices. We have developed a molecular signature that could serve as a companion diagnostic and uses bulk or spatial transcriptomic data to identify a unique subclass of liver tumors. This subgroup of liver cancer patients derive limited benefit from the current standard of care and are expected to benefit from specialized directed therapies that are on the horizon.
Authors
- Catherine Cao
- Junyan Tao (ORCID: https://orcid.org/0000-0002-5249-970X)
- Sucha Singh (ORCID: https://orcid.org/0000-0002-9131-1423)
- Théo Z. Hirsch (ORCID: https://orcid.org/0000-0003-4428-2997)
- Aatur Dilip Singhi (ORCID: https://orcid.org/0000-0003-3930-7096)
- Brandon M. Lehrich (ORCID: https://orcid.org/0000-0003-1003-5605)
- Silvia Liu (ORCID: https://orcid.org/0000-0002-1840-9520)
- Satdarshan P. Monga (ORCID: https://orcid.org/0000-0002-8437-3378)
- Evan R. Delgado (ORCID: https://orcid.org/0000-0003-2706-0946)
- Long Pan (ORCID: https://orcid.org/0000-0003-1550-8280)
- Jessica Zucman‐Rossi (ORCID: https://orcid.org/0000-0002-5687-0334)
- Aaron Bell (ORCID: https://orcid.org/0000-0001-6648-0834)
- Tyler M. Yasaka (ORCID: https://orcid.org/0000-0002-8482-0369)
- Xiangnan Guan
- Yulei Wang (ORCID: https://orcid.org/0000-0002-9057-9786)
- Shan Lu (ORCID: https://orcid.org/0000-0002-9756-7198)
- Y. Liu (ORCID: https://orcid.org/0009-0009-0811-9229)
- Minakshi Poddar
Institutions
- Inserm (FR)
- University of Pittsburgh (US)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101186
- Citations
- 16
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.72
Funders
- University of Pittsburgh
- National Institutes of Health
- Center for Research Computing, University of Pittsburgh
- Pittsburgh Liver Research Center, University of Pittsburgh
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Biomedical Imaging and Bioengineering