Fecal deoxycholic acid associates with diet, intestinal microbes, and total bilirubin in primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a cholestatic liver disease with a direct interaction between the gut and the liver. In this study of patients with early-stage PSC, levels of fecal deoxycholic acid correlated with serum total bilirubin, a marker of clinical outcomes. In addition, <i>Blautia</i> and <i>Lachnoclostridium</i> were associated with fecal deoxycholic acid suggesting an interaction between these gut bacteria, fecal bile acids, and disease progression. Future research to determine the underlying mechanisms of these associations may lead to novel targets to prevent PSC disease progression.
Authors
- Christopher L. Bowlus (ORCID: https://orcid.org/0000-0002-3906-6811)
- William F. Gagnon
- Joseph Zepeda (ORCID: https://orcid.org/0009-0001-0484-6762)
- Peter Finnegan
- Richard E. Dean
- Connie Chan
- Joshua R. Korzenik (ORCID: https://orcid.org/0000-0001-7692-5710)
- Olivier Barbier (ORCID: https://orcid.org/0000-0002-3067-1134)
- Michael A Trauner (ORCID: https://orcid.org/0000-0002-1275-6425)
- Marie‐Claude Vohl
- Maria L. Marco (ORCID: https://orcid.org/0000-0002-3643-9766)
- Maryam Yazdanafar
- Mateus Lacerda Pereira Lemos (ORCID: https://orcid.org/0000-0002-2006-1826)
Institutions
- Brigham and Women's Hospital (US)
- Canadian Nutrition Society (CA)
- Université Laval (CA)
- Medical University of Vienna (AT)
- University of California, Davis (US)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101188
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Canadian Institutes of Health Research