Comparing the Effect of Intravenous Tramadol and Intravenous Nalbuphine in Addition to Midazolam for the Control of Shivering after Spinal Anesthesia

Introduction Shivering is a common complication during neuraxial anesthesia, leading to metabolic and cardiovascular challenges. Existing treatments vary in effectiveness, and this study compares intravenous tramadol and nalbuphine, both administered with midazolam, for shivering control. Objectives To evaluate and compare the efficacy of IV tramadol and IV nalbuphine, alongside midazolam, in controlling post-spinal anesthesia shivering. Materials and Methods A prospective, randomized comparative clinical study involving 100 patients undergoing various surgical procedures under spinal anesthesia. Patients were divided into two groups to receive either IV Tramadol or IV Nalbuphine with midazolam. Parameters like shivering severity, time to cessation, recurrence, and side effects were recorded and analyzed. Results Both tramadol and nalbuphine effectively controlled shivering with comparable response times and side effect profiles. There was no significant difference in the incidence of nausea, vomiting, and sedation between the groups. Hemodynamic stability was maintained throughout the study. Conclusion IV tramadol and IV nalbuphine, in conjunction with midazolam, are effective in controlling post-spinal anesthesia shivering, with similar efficacy and safety profiles. They provide valuable options for clinicians in managing this common anesthetic complication. Further research is encouraged for more refined application in diverse patient populations.

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Publication Details

Journal
Journal of Pharmacology and Pharmacotherapeutics
Published
2024-08-23
DOI
https://doi.org/10.1177/0976500x241262076
Citations
2
Primary Topic
Thermal Regulation in Medicine
Type
article
Field-Weighted Citation Impact
0.84
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article

Comparing the Effect of Intravenous Tramadol and Intravenous Nalbuphine in Addition to Midazolam for the Control of Shivering after Spinal Anesthesia

Rebecca Shin-Yee Wong, Long Chiau Ming, Khang Wen Goh, Wen Han Chooi et al.
2 citations
Journal of Pharmacology and Pharmacotherapeutics
Thermal Regulation in Medicine
0.84
article

Comparing the Effect of Intravenous Tramadol and Intravenous Nalbuphine in Addition to Midazolam for the Control of Shivering after Spinal Anesthesia

Rebecca Shin-Yee Wong, Long Chiau Ming, Khang Wen Goh, Wen Han Chooi, Dinakar Mallem, Ali Saleh Alkhoshaiban, Vijay Kotra, Apoorva Madem, Sravanthi Parusha, Indira Pacharla
article en
2 citations

Abstract

Introduction Shivering is a common complication during neuraxial anesthesia, leading to metabolic and cardiovascular challenges. Existing treatments vary in effectiveness, and this study compares intravenous tramadol and nalbuphine, both administered with midazolam, for shivering control. Objectives To evaluate and compare the efficacy of IV tramadol and IV nalbuphine, alongside midazolam, in controlling post-spinal anesthesia shivering. Materials and Methods A prospective, randomized comparative clinical study involving 100 patients undergoing various surgical procedures under spinal anesthesia. Patients were divided into two groups to receive either IV Tramadol or IV Nalbuphine with midazolam. Parameters like shivering severity, time to cessation, recurrence, and side effects were recorded and analyzed. Results Both tramadol and nalbuphine effectively controlled shivering with comparable response times and side effect profiles. There was no significant difference in the incidence of nausea, vomiting, and sedation between the groups. Hemodynamic stability was maintained throughout the study. Conclusion IV tramadol and IV nalbuphine, in conjunction with midazolam, are effective in controlling post-spinal anesthesia shivering, with similar efficacy and safety profiles. They provide valuable options for clinicians in managing this common anesthetic complication. Further research is encouraged for more refined application in diverse patient populations.

Journal of Pharmacology and PharmacotherapeuticsVol. 15(3)
INTI International University (MY), Qassim University (SA), MNJ Institute Of Oncology and Regional Cancer Centre (IN), Apollo Institute of Medical Sciences & Research (IN), Quest International University Perak (MY), Sunway University (MY)
Good health and well-being
Openalex Percentile: Top 27%
Thermal Regulation in Medicine
0.84
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