Evolutionary Analysis of the Mammalian IL‐17 Cytokine Family Suggests Conserved Roles in Female Fertility
The conservation of the IL-17 gene and protein across mammals suggests similar functions in all the analysed species. Despite significant differences, the upregulation of IL-17 expression is associated with the establishment of pregnancy in eutherian and metatherian mammals. The dysregulation of IL-17s in human reproductive disorders suggests them as a potential therapeutic target.
Authors
- Federica Giangrazi (ORCID: https://orcid.org/0000-0003-3666-475X)
- Andrew T. Lloyd (ORCID: https://orcid.org/0000-0001-9989-7652)
- Louise Glover (ORCID: https://orcid.org/0000-0001-9056-1810)
- Anthony K. Redmond (ORCID: https://orcid.org/0000-0002-7895-2410)
- Dafne Buffa
- Cliona O’Farrelly (ORCID: https://orcid.org/0000-0002-0616-2874)
Institutions
- University College Dublin (IE)
- National University of Ireland, Maynooth (IE)
- Trinity College Dublin (IE)
- Merrion Fertility Clinic (IE)
- Institute of Technology Carlow (IE)
Publication Details
- Journal
- American Journal of Reproductive Immunology
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1111/aji.13907
- Citations
- 2
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- Merck KGaA
- Science Foundation Ireland