PUS7‐dependent pseudouridylation of <i>ALKBH3</i> mRNA inhibits gastric cancer progression
PUS7 enhances the translation efficiency of ALKBH3 through its pseudouridylation activity on ALKBH3 mRNA, thereby inhibiting gastric tumourigenesis. The expression levels of PUS7 and ALKBH3 are significantly correlated in gastric tumours, which may be potential prognostic predictors and therapeutic targets for patients with gastric cancer.
Authors
- Kang‐Hua Chen (ORCID: https://orcid.org/0000-0001-9782-3633)
- Wei Liu (ORCID: https://orcid.org/0000-0002-0980-7818)
- Zhangqi Xu (ORCID: https://orcid.org/0009-0005-0187-3211)
- Aifu Lin (ORCID: https://orcid.org/0000-0002-3968-3617)
- Shanshan Xie (ORCID: https://orcid.org/0000-0003-4294-8169)
- Yun Cui (ORCID: https://orcid.org/0000-0003-1688-3744)
- Wenjun Kuang (ORCID: https://orcid.org/0009-0000-5541-0144)
- Chunxiao Huo (ORCID: https://orcid.org/0009-0008-0442-4608)
- Hao Jin (ORCID: https://orcid.org/0000-0003-1262-1675)
- Bo Yang (ORCID: https://orcid.org/0000-0002-3183-5567)
- Tianhua Zhou (ORCID: https://orcid.org/0000-0002-1791-2124)
- Yongxia Chang (ORCID: https://orcid.org/0009-0008-7982-0533)
- Yang Feng (ORCID: https://orcid.org/0000-0002-7976-1640)
- Ya Li (ORCID: https://orcid.org/0000-0001-8538-4522)
Institutions
- Zhejiang Cancer Hospital (CN)
- Children's Hospital of Zhejiang University (CN)
- Hangzhou City University
- Zhejiang University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/ctm2.1811
- Citations
- 24
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.61
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities