Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension
This study discovers a previously unrecognized role of GPR183 in promoting endothelial senescence. Pharmacological targeting of GPR183 may be an innovative therapeutic strategy for hypertension and its associated complications.
Authors
- Qingqing Chu (ORCID: https://orcid.org/0009-0009-0264-8592)
- Fan Yi (ORCID: https://orcid.org/0000-0001-8634-9788)
- Guo Xiangyun (ORCID: https://orcid.org/0009-0003-3749-6011)
- Huili Hu (ORCID: https://orcid.org/0000-0002-1239-7127)
- Peng Zhan (ORCID: https://orcid.org/0000-0002-9675-6026)
- Min Liu (ORCID: https://orcid.org/0000-0001-5671-9653)
- Xiaojie Wang (ORCID: https://orcid.org/0000-0003-4817-5830)
- Tao Zhang (ORCID: https://orcid.org/0000-0003-1048-4443)
- Hong Liu (ORCID: https://orcid.org/0000-0002-4110-6333)
- Jin‐Peng Sun (ORCID: https://orcid.org/0000-0003-3572-1580)
- Hang Lv (ORCID: https://orcid.org/0009-0005-1469-3340)
- Wei Tang (ORCID: https://orcid.org/0000-0002-4573-3502)
- Yujia Li (ORCID: https://orcid.org/0009-0002-2785-0948)
- Jichao Wu (ORCID: https://orcid.org/0009-0001-9344-5409)
- Jing Li (ORCID: https://orcid.org/0000-0002-8430-2772)
- Yanjiao Gao
Institutions
- Shandong University (CN)
- Ministry of Education (BD)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1161/circresaha.124.324722
- Citations
- 16
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 3.74