Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles inhibit neuronal death after spinal cord injury by regulating the SIRT1/Nrf2/HO-1 pathway
Our study provides valuable insights into the effects of H-sEVs on neuronal oxidative stress and apoptosis after SCI. These findings underscore the potential clinical significance of H-sEVs-based therapies for SCI.
Authors
- Zeyan Liang
- Yike Lin
- Maochao Zhou
- Fabin Lin (ORCID: https://orcid.org/0000-0001-7628-9152)
- Haishu Xie
- Zhelun Yang (ORCID: https://orcid.org/0000-0002-6332-5879)
- Xiongjie Xu
- Jian Rao
- Chun‐Hua Wang (ORCID: https://orcid.org/0000-0002-3514-9353)
- Rui Wang (ORCID: https://orcid.org/0000-0002-5490-8271)
- Chunmei Chen (ORCID: https://orcid.org/0000-0002-4483-7465)
- Pingping Chen (ORCID: https://orcid.org/0000-0002-2848-2465)
Institutions
- Fujian Medical University (CN)
- Fujian Institute of Microbiology (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3389/fphar.2024.1419390
- Citations
- 10
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- Natural Science Foundation of Fujian Province