Dissection of the cell communication interactions in lung adenocarcinoma identified a prognostic model with immunotherapy efficacy assessment and a potential therapeutic candidate gene ITGB1
Our study elucidates molecular patterns and cell communication interactions in LUAD as effective biomarkers and predictors of immunotherapy response. Targeting cell communication interactions offers novel avenues for LUAD immunotherapy and prognostic evaluations, with ITGB1 emerging as a promising therapeutic target.
Authors
- Xing Jin (ORCID: https://orcid.org/0000-0002-9739-3263)
- Zhenyu Liao (ORCID: https://orcid.org/0000-0003-4691-1400)
- Ye Cheng (ORCID: https://orcid.org/0000-0002-7380-8233)
- Guangyao Shan (ORCID: https://orcid.org/0000-0002-2993-5817)
- Zhencong Chen (ORCID: https://orcid.org/0000-0003-2763-9667)
- Guoshu Bi (ORCID: https://orcid.org/0000-0003-2187-5271)
- Zhengyang Hu (ORCID: https://orcid.org/0000-0003-4541-1826)
- Junjie Xi (ORCID: https://orcid.org/0000-0002-1766-7149)
- Jiaqi Liang (ORCID: https://orcid.org/0000-0002-4738-4238)
- Mengnan Zhao (ORCID: https://orcid.org/0000-0002-2337-3278)
- Jiacheng Yin
- Miao Lin (ORCID: https://orcid.org/0009-0004-2634-3690)
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e36599
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.28