Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer
Collectively, these findings highlight the therapeutic potential of targeting IRP2 to exploit the disruption of iron metabolism in CRC, presenting a strategic advancement in addressing a critical area of unmet clinical need.
Authors
- Jaesung Kwak (ORCID: https://orcid.org/0000-0001-8010-7307)
- Xianghua Zhao (ORCID: https://orcid.org/0000-0002-9449-3859)
- Jaemoon Yang (ORCID: https://orcid.org/0000-0001-7365-0395)
- Hocheol Lim (ORCID: https://orcid.org/0000-0002-4678-8062)
- Byungil Kim (ORCID: https://orcid.org/0000-0002-1743-2657)
- Uyeong Choi
- Ayoung Baek
- Jieon Hwang
- Minhee Ku (ORCID: https://orcid.org/0000-0002-1674-1474)
- Chang Gon Kim (ORCID: https://orcid.org/0000-0002-4929-8501)
- Sang Joon Shin (ORCID: https://orcid.org/0000-0001-5350-7241)
- Kyoung Tai No (ORCID: https://orcid.org/0000-0003-3187-8193)
- Kyu‐Sung Jeong (ORCID: https://orcid.org/0000-0003-1023-1796)
- Hyun‐Jin Shin (ORCID: https://orcid.org/0000-0002-6805-4924)
- Tae Il Kim (ORCID: https://orcid.org/0000-0003-4807-890X)
- Hyuk Lee (ORCID: https://orcid.org/0000-0002-5791-3826)
- Areum Park (ORCID: https://orcid.org/0000-0002-9661-4319)
- Jiwon Choi
- Chinwoo Kim
Institutions
- Dongduk Women's University (KR)
- Yonsei University (KR)
- Korea Research Institute of Chemical Technology (KR)
- Yonsei University Health System (KR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1186/s12964-024-01769-6
- Citations
- 15
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.82
Funders
- National Research Foundation
- Korea Research Institute of Chemical Technology
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea