Distinct regional vulnerability to Aβ and iron accumulation in <i>post mortem</i> AD brains
The vulnerability of distinct brain regions to amyloid beta (Aβ) and iron accumulation varies. Histological validation was performed on stained sections of ex-vivo human brains. Regional variations in susceptibility were linked to gene expression profiles. Iron and Aβ levels in ex-vivo brains were simultaneously quantified.
Authors
- Junye Yao (ORCID: https://orcid.org/0000-0002-8633-8744)
- Ai‐Min Bao (ORCID: https://orcid.org/0000-0002-8755-1950)
- Hong‐Jiang Wei (ORCID: https://orcid.org/0000-0002-5663-1093)
- Hongjian He (ORCID: https://orcid.org/0000-0001-6272-0810)
- Zheng Wang (ORCID: https://orcid.org/0000-0001-7138-8581)
- Zhenghao Li (ORCID: https://orcid.org/0000-0002-2047-5041)
- Zihan Zhou (ORCID: https://orcid.org/0000-0002-9034-0951)
Institutions
- Allen Institute for Brain Science (US)
- McGovern Institute for Brain Research (US)
- Shanghai Jiao Tong University (CN)
- Peking University (CN)
- Hainan University (CN)
- Chinese Institute for Brain Research (CN)
- Zhejiang Lab (CN)
- Center for Life Sciences (CN)
- Zhejiang University (CN)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1002/alz.14188
- Citations
- 13
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities