Metabolomic Profile Alterations Associated with the SLC16A11 Risk Haplotype Following a Lifestyle Intervention in People With Prediabetes
Our study highlights the persistence of deleterious metabolomic patterns associated with the risk haplotype before and during a 24-wk LSI. We also emphasize the potential regulatory role of polyunsaturated fatty acids on methylmalonylcarnitine concentrations suggesting a route for improving interventions for individuals with high-genetic risk.
Authors
- Magdalena Sevilla-González (ORCID: https://orcid.org/0000-0001-6135-9998)
- Arsenio Vargas‐Vázquez (ORCID: https://orcid.org/0000-0002-0051-7689)
- María Luisa Ordóñez-Sánchez (ORCID: https://orcid.org/0000-0003-1354-451X)
- Clary B. Clish (ORCID: https://orcid.org/0000-0001-8259-9245)
- Andrea Celeste Medina-García (ORCID: https://orcid.org/0000-0001-7655-2782)
- Paloma Almeda‐Valdés (ORCID: https://orcid.org/0000-0002-9701-5879)
- Maria Fernanda Garibay-Gutiérrez
- Teresa Tusié‐Luna
Institutions
- Broad Institute (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Instituto Politécnico Nacional (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.cdnut.2024.104444
- Citations
- 3
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- American Diabetes Association
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases