Nickel Doped Hydroxyapatite Nanocomposite via Salt Melting Approach: A Colorimetric Sensing Platform for the Determination of Ascorbic Acid
Abnormal levels of ascorbic acid in the human body can induce various diseases. We reported a nickel-doped hydroxyapatite (Ni-HAp)-based biosensor for ascorbic acid and confirmed it through various spectroscopic techniques. Ni-HAp demonstrated peroxidase-like activity that was detected through the chromogenic substrate. The analyte produces a color change from blue-green to colorless. The optimized sensor has a correlation coefficient of 0.997, a limit of detection of 0.11 µM, a limit of quantification value of 0.36 µM, and a linear range from 2 to 47 µM for ascorbic acid. The synthesized sensor was used to determine ascorbic acid in spiked physiological solutions.
Authors
- A. Badshah (ORCID: https://orcid.org/0000-0002-7268-6692)
- Umar Nishan (ORCID: https://orcid.org/0000-0002-0106-3068)
- Naeem Khan (ORCID: https://orcid.org/0000-0002-7365-1168)
- Mohamed Akhiruddin Ibrahim (ORCID: https://orcid.org/0000-0003-3918-2879)
- Mohibullah Shah (ORCID: https://orcid.org/0000-0001-6126-7102)
- Muhammad Ishtiaq Jan (ORCID: https://orcid.org/0000-0003-2770-3040)
- Mansoor Ahmad (ORCID: https://orcid.org/0009-0001-7018-0823)
- Wei Sun (ORCID: https://orcid.org/0000-0002-9923-7328)
- Muhammad Asad (ORCID: https://orcid.org/0000-0002-9573-0852)
- Riaz Ullah (ORCID: https://orcid.org/0000-0002-2860-467X)
- Essam A. Ali (ORCID: https://orcid.org/0000-0001-6083-5913)
- Ambreen Shahbaz
Institutions
- Bahauddin Zakariya University (PK)
- Hainan Normal University (CN)
- Kohat University of Science and Technology (PK)
- King Saud University (SA)
Publication Details
- Journal
- Analytical Letters
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1080/00032719.2024.2392648
- Citations
- 4
- Primary Topic
- Electrochemical sensors and biosensors
- Type
- article
- Field-Weighted Citation Impact
- 0.83
Funders
- King Saud University