Therapeutic Effect of Essential Oils (Citrus sinensis) against Ehrlich Ascites Model Induced Renal Toxicity in Female Mice

Background: Cancer is one of the most dangerous diseases of the twentieth century and the speed of its spread is horrific. It is characterized by cellular growth and invades all tissues of the body. In recent years, all countries of the world have turned to cancer research in order to identify new drugs to treat cancer from various sources , Cancer is the most common disease that causes death in the world and this is attributed to many pathological factors, such as reactive oxygen species, which contribute to the initiation, spread and development of cancer. Methods: Our current research aims to investigate the therapeutic role of essential oils (C.S.) against Ehrlich Tumor renal damage in Mice. The mice were divided into four group (Gp1, control group, Gp2, Essential oils (C.S) group, Gp3, EAC group, Gp4, EAC with Essential oils (C.S). Result: Results showed the Essential oils (C.S) in pretreated (G4) lead to an improvement in urea, creatinine levels when compared to the EAC group. Through our results, it was shown that treatment with essential oils (C.S.) improved the levels of urea and creatinine comparing to the Gp3. It was noted that treatment with essential oils (C.S.) improved kidney tissue and VEGF protein expression the Gp4 compared to the Gp3 Groups. It could be concluded that essential oils (C.S) has a possible benefit to the kidneys against EAC induce kidney Toxicity.