Revisiting Utility of Fetal Autopsy in Genomic Era

<b>Background:</b> Autopsy has been a gold standard in cases of antenatal detected anomalies or fetal demise. This helped clinicians in getting insights into the future management. In current times, ultrasound and genomic testing has become extremely powerful in further refining the etiological basis; however, fetal autopsy still has its role even now. <b>Material and Methods:</b> We have discussed the utility of fetal autopsy in current times by diving the cases in seven groups. <b>Results:</b> Case based discussions to discuss the utility of fetal autopsy. <b>Conclusions:</b> We suggest that fetal autopsy should be the standard of care in case of any abnormal fetal outcomes alongwith fetal genomic testing. Fetal autopsy is complementary to the ultrasound assessment and genomic investigations in reaching the final diagnosis and provides invaluable information regarding recurrence risk which may not be available when couple plans next pregnancy.

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Publication Details

Journal
Fetal and Pediatric Pathology
Published
2024-08-23
DOI
https://doi.org/10.1080/15513815.2024.2393356
Primary Topic
Autopsy Techniques and Outcomes
Type
article
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article

Revisiting Utility of Fetal Autopsy in Genomic Era

Preeti Paliwal, Seema Thakur, Chanchal Singh, Gurnihal Singh Chawla et al.
Fetal and Pediatric Pathology
Autopsy Techniques and Outcomes
article

Revisiting Utility of Fetal Autopsy in Genomic Era

Preeti Paliwal, Seema Thakur, Chanchal Singh, Gurnihal Singh Chawla, Vrunda Appannagri, N. Mohit, Rounak Bagga
article en

Abstract

<b>Background:</b> Autopsy has been a gold standard in cases of antenatal detected anomalies or fetal demise. This helped clinicians in getting insights into the future management. In current times, ultrasound and genomic testing has become extremely powerful in further refining the etiological basis; however, fetal autopsy still has its role even now. <b>Material and Methods:</b> We have discussed the utility of fetal autopsy in current times by diving the cases in seven groups. <b>Results:</b> Case based discussions to discuss the utility of fetal autopsy. <b>Conclusions:</b> We suggest that fetal autopsy should be the standard of care in case of any abnormal fetal outcomes alongwith fetal genomic testing. Fetal autopsy is complementary to the ultrasound assessment and genomic investigations in reaching the final diagnosis and provides invaluable information regarding recurrence risk which may not be available when couple plans next pregnancy.

Fetal and Pediatric PathologyVol. 43(6)
Rainbow Children's Hospital (IN), Fortis Hospital (IN)
Zero hunger
Openalex Percentile: Top 77%
Autopsy Techniques and Outcomes
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