Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis
We present five patients with ALK-driven relapsed or refractory neuroblastoma treated with lorlatinib as monotherapy. All patients responded to treatment, and four of them were alive after 3 to 5 years of follow-up. We performed longitudinal ctDNA analysis with ultra-deep sequencing of the ALK tyrosine kinase domain. We conclude that ctDNA analysis may guide treatment decisions in ALK-driven neuroblastoma, also when the disease is undetectable using standard clinical methods.
Authors
- Ruth H. Palmer (ORCID: https://orcid.org/0000-0002-2735-8470)
- Ida Rahmqvist (ORCID: https://orcid.org/0009-0007-4665-7023)
- Lina Hansson
- Henrik Fagman (ORCID: https://orcid.org/0000-0001-5853-6295)
- Anders Ståhlberg (ORCID: https://orcid.org/0000-0003-4243-0191)
- Fani Pujol-Calderón (ORCID: https://orcid.org/0000-0001-7920-2884)
- Bronte Manouk Verhoeven
- Jennie Gaarder (ORCID: https://orcid.org/0009-0001-3890-1862)
- Bengt Hallberg (ORCID: https://orcid.org/0000-0003-2032-2616)
- Kleopatra Georgantzi (ORCID: https://orcid.org/0000-0001-9304-6144)
- Martin G. Dalin (ORCID: https://orcid.org/0000-0002-7516-0004)
- Catarina Träger
- Tzu‐Po Chuang (ORCID: https://orcid.org/0000-0001-5676-4112)
- Diana Treis (ORCID: https://orcid.org/0000-0002-7887-9436)
- Susanne Fransson (ORCID: https://orcid.org/0000-0002-9713-3074)
- Tobias Österlund (ORCID: https://orcid.org/0000-0002-7870-8645)
- Per Kogner (ORCID: https://orcid.org/0000-0002-2202-9694)
- Tommy Martinsson (ORCID: https://orcid.org/0000-0002-9403-3123)
- Torben Ek (ORCID: https://orcid.org/0000-0002-0518-983X)
- Hartmut Vogt (ORCID: https://orcid.org/0000-0001-6009-7789)
- Anna Djos (ORCID: https://orcid.org/0000-0002-5250-2163)
- Raghda R. Ibrahim (ORCID: https://orcid.org/0000-0001-7641-3141)
- Christoffer Vannas (ORCID: https://orcid.org/0000-0002-1029-0393)
- Elisabeth Mellström (ORCID: https://orcid.org/0009-0004-2801-1681)
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Uppsala University Hospital (SE)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- Region Västra Götaland (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0338
- Citations
- 10
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.69