Genomic and Epigenomic Analysis of Plasma Cell-Free DNA Identifies Stemness Features Associated with Worse Survival in Lethal Prostate Cancer
We analyzed a total of 220 patients with mCRPC, validated the importance of cell-free AR/enhancer alterations as a prognostic biomarker in lethal mCRPC, and showed that the underlying mechanism for lethality involves reprogramming developmental states toward increased stemness. See related commentary by Nawfal et al., p. 7.
Authors
- Sean S. Park (ORCID: https://orcid.org/0000-0003-3814-853X)
- Jacob J. Orme (ORCID: https://orcid.org/0000-0002-0319-0239)
- Ramandeep K. Babbra (ORCID: https://orcid.org/0000-0002-6244-5107)
- Irfan Alahi (ORCID: https://orcid.org/0009-0008-4577-3548)
- Jace Webster (ORCID: https://orcid.org/0000-0002-9396-5658)
- Chad Z. Tang (ORCID: https://orcid.org/0000-0002-5915-1327)
- Alexander D. Sherry (ORCID: https://orcid.org/0000-0001-5115-1691)
- Sydney Caputo (ORCID: https://orcid.org/0000-0001-7901-367X)
- Dzifa Y. Duose (ORCID: https://orcid.org/0000-0002-6763-9736)
- Peter K. Harris (ORCID: https://orcid.org/0000-0003-1557-1722)
- Alexander L. Shiang (ORCID: https://orcid.org/0000-0002-7957-5418)
- Christopher A. Maher (ORCID: https://orcid.org/0000-0002-9035-603X)
- Lilli Greiner (ORCID: https://orcid.org/0009-0007-5531-2991)
- Wenjia Feng (ORCID: https://orcid.org/0000-0002-6320-3927)
- Ryan Mueller (ORCID: https://orcid.org/0009-0009-7156-4990)
- Savar Sinha (ORCID: https://orcid.org/0000-0003-0155-0883)
- Elisa M. Ledet (ORCID: https://orcid.org/0000-0003-1230-3255)
- Faridi Qaium
- Ellen Jaeger (ORCID: https://orcid.org/0009-0005-1386-614X)
- Gabris Ni (ORCID: https://orcid.org/0009-0008-3901-6508)
- Aadel A. Chaudhuri (ORCID: https://orcid.org/0000-0003-3115-3061)
- Breanna Yang (ORCID: https://orcid.org/0009-0005-5981-9699)
- Oliver A. Sartor (ORCID: https://orcid.org/0000-0002-8777-7343)
- Ha X. Dang (ORCID: https://orcid.org/0000-0002-9342-9249)
- Russell K. Pachynski (ORCID: https://orcid.org/0000-0002-8966-7631)
- Pradeep S. Chauhan (ORCID: https://orcid.org/0000-0003-4304-011X)
- Fabrice Lucien (ORCID: https://orcid.org/0000-0001-6149-345X)
- Debanjan Saha (ORCID: https://orcid.org/0000-0001-7483-7231)
- Jessica Linford
- Steven Alexander (ORCID: https://orcid.org/0000-0002-4074-6099)
- Patrick J. Miller
Institutions
- James S. McDonnell Foundation (US)
- Tulane University (US)
- Cedars-Sinai Medical Center (US)
- Mayo Clinic (US)
- The University of Texas MD Anderson Cancer Center (US)
- Washington University in St. Louis (US)
- Ochsner Baptist Medical Center (US)
- University of Rochester Medical Center (US)
- Cancer Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1658
- Citations
- 8
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- U.S. Department of Defense
- V Foundation for Cancer Research
- Amgen
- Pfizer
- AstraZeneca
- Sanofi
- Cancer Prevention and Research Institute of Texas
- Exelixis
- National Comprehensive Cancer Network
- Advanced Accelerator Applications
- Genentech
- Pharmacyclics
- National Cancer Institute