Redox-Active α-Amino-CF<sub>3</sub> Reagents: Developing and Applications in Ni-Catalyzed Reductive Cross-Coupling
α-Amino-CF<sub>3</sub> compounds are widely employed in bio- and pharmaceutical chemistry for improved stability and bioactivities. Traditional methods often face challenges with functional group tolerance and lack a general approach for late-stage functionalization. Herein, we report a new type of redox-active α-amino-CF<sub>3</sub> reagents, easily prepared from trifluoro acetaldehyde hydrates. These α-amino-CF<sub>3</sub> reagents can serve as versatile building blocks for coupling with alkynyl bromides, aryl bromides, and enol triflates under nickel catalysis.
Authors
- Yifan Ni
- Liang Yan (ORCID: https://orcid.org/0000-0003-4528-4361)
- Shengyang Ni (ORCID: https://orcid.org/0000-0002-6866-8440)
- Jiyang Liu (ORCID: https://orcid.org/0000-0003-3699-1646)
- Ying Wang (ORCID: https://orcid.org/0000-0003-4524-1812)
- Yi Pan (ORCID: https://orcid.org/0000-0002-1873-2731)
- Yu Mao
Institutions
- Wannan Medical College (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1021/acs.orglett.4c02730
- Citations
- 6
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Jiangsu Province