Cytotoxic Effects of Oleanane‐ <i>type</i> Saponins from <i>Lysimachia laxa</i>
Phytochemical investigation of the methanol extract of the aerial parts of Lysimachia laxa led to the isolation of four new oleanane-type saponins, lysimosides A-D (1-4) and one known compound, lysimachigenoside B (5). Their structures were elucidated using a combination of HR-ESI-MS, 1D and 2D-NMR spectral data, chemical methods, and comparison with previous literature. The cytotoxic activity of these compounds was evaluated against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines. All compounds exhibited cytotoxic activity against A-549 and MCF-7 cell lines with IC<sub>50</sub> values ranging from 6.1-16.0 μM, comparable to the positive control, mitoxantrone. Interestingly, oleanane-type saponins with an acetyl group (2-4) exhibited increased cytotoxic activities compared to those without an acetyl group (1).
Authors
- Phan Văn Kiệm (ORCID: https://orcid.org/0000-0003-0756-6990)
- Bùi Hữu Tài (ORCID: https://orcid.org/0000-0002-2034-3786)
- Nguyễn Xuân Nhiệm (ORCID: https://orcid.org/0000-0002-1161-6498)
- Nguyễn Thị Vân Anh (ORCID: https://orcid.org/0000-0002-8720-8255)
- Nguyễn Thị Son (ORCID: https://orcid.org/0009-0008-0788-3391)
- Le Thi Huyen (ORCID: https://orcid.org/0000-0001-7492-8360)
- Nguyen Thi Hanh (ORCID: https://orcid.org/0000-0001-6348-2471)
- Nguyen Thi Thuy (ORCID: https://orcid.org/0000-0003-2342-3797)
- Dang Gia Bao
- Phan Thị Thanh Hương
- Seon-Ju Park
Institutions
- Vietnam National University, Hanoi (VN)
- Le Hong Phong High School for the Gifted (VN)
- Institute for Nuclear Science and Technology (VN)
- Korea Basic Science Institute (KR)
- VNU University of Science (VN)
- Vietnam Academy of Science and Technology (VN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1002/cbdv.202401024
- Citations
- 4
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.94