Simulating combined monoaminergic depletions in a PD animal model through a bio-constrained differential equations system
Our holistic approach emphasizes that PD is a multifactorial disorder and opens promising avenues for early diagnostic tools that harness the intricate interactions among monoaminergic systems. Investigating NA and 5-HT systems alongside the DA system may yield more effective, subtype-specific therapies. The exploration of multisystem dysregulation in PD is poised to revolutionize our understanding and management of this complex neurodegenerative disorder.
Authors
- Luigi Brugnano (ORCID: https://orcid.org/0000-0002-6290-4107)
- Daniele Caligiore (ORCID: https://orcid.org/0000-0002-3040-9961)
- Samuele Carli (ORCID: https://orcid.org/0000-0002-3250-2465)
Institutions
- Superconducting and other Innovative Materials and Devices Institute (IT)
- National Research Council (IT)
- Institute of Cognitive Sciences and Technologies (IT)
- University of Florence (IT)
Publication Details
- Journal
- Frontiers in Computational Neuroscience
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3389/fncom.2024.1386841
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- Fondazione Italiana Sclerosi Multipla