Genetic Screen in a Preclinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities
Transcriptional co-analysis of TCGA patient samples to YAP1 and KRAS model tumors supports that these sarcoma subtypes lie along a spectrum of disease and adds guidance for further transcriptome-based refinement of sarcoma subtyping. This approach can be used to begin to understand pathways and mechanisms driving human sarcoma development, the relationship between sarcoma subtypes, and to identify and validate new therapeutic vulnerabilities for this aggressive and heterogeneous disease.
Authors
- Edmond F. O’Donnell (ORCID: https://orcid.org/0000-0001-9110-9981)
- Janai R. Carr (ORCID: https://orcid.org/0000-0002-2074-4643)
- Kathrin Plath (ORCID: https://orcid.org/0000-0001-7796-3372)
- Thomas G. Graeber (ORCID: https://orcid.org/0000-0001-8574-9181)
- Kermit L. Carraway (ORCID: https://orcid.org/0000-0003-0664-9591)
- Maria Muñoz
- Justin Langerman
- Julissa Suarez-Navarro (ORCID: https://orcid.org/0000-0002-6484-7433)
- Jack Freeland (ORCID: https://orcid.org/0000-0002-8547-1869)
- Steven W. Thorpe (ORCID: https://orcid.org/0000-0003-3127-4912)
- R. Lor Randall (ORCID: https://orcid.org/0000-0002-3660-774X)
- Morgan Darrow
- Robert J. Canter (ORCID: https://orcid.org/0000-0002-3331-5418)
- Owen N. Witte (ORCID: https://orcid.org/0000-0003-4461-4533)
- Jessica Bergonio
Institutions
- University of California, Los Angeles (US)
- Los Angeles Medical Center (US)
- Broad Center (US)
- University of California Davis Medical Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1238
- Citations
- 1
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Howard Hughes Medical Institute
- Burroughs Wellcome Fund
- Doris Duke Charitable Foundation
- W. M. Keck Foundation
- Alan B. Slifka Foundation
- National Institutes of Health
- University of California, Davis
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institute of Arthritis and Musculoskeletal and Skin Diseases