Network pharmacology and single-cell transcriptomic analysis with molecular docking to elucidate the potential compounds and targets of Polygonum cuspidatum Sieb.et Zucc. for hepatocellular carcinoma
Our study provides novel insights into the anti-hepatocellular carcinoma pharmacological effects of <i>P. cuspidatum</i>, which could serve as a scientific basis for its development as a medicinal resource and the targeting of CDK1 for hepatocellular carcinoma treatment.
Authors
- Weidi Zhao
- Wenze Wu (ORCID: https://orcid.org/0009-0007-9571-694X)
- Gang Ye (ORCID: https://orcid.org/0000-0001-7382-3938)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-6147-1573)
- Zhiyuan Chen (ORCID: https://orcid.org/0000-0002-9828-5272)
- Xinyan Wu (ORCID: https://orcid.org/0000-0002-7745-1614)
- Yongzi Wu
- Yuzhu Shi
Institutions
- Shanxi University (CN)
- Sichuan Agricultural University (CN)
- Northeastern University (CN)
Publication Details
- Journal
- iLiver
- Published
- 2024-08-23
- DOI
- https://doi.org/10.1016/j.iliver.2024.100115
- Citations
- 2
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.72