Exposure of Ldlr−/− Mice to a PFAS Mixture and Outcomes Related to Circulating Lipids, Bile Acid Excretion, and the Intestinal Transporter ASBT
Mice exposed to a PFAS mixture displayed higher circulating cholesterol and bile acids perhaps due to impacts on enterohepatic circulation. This study implicates PFAS-mediated effects at the site of the ileum as a possible critical mediator of increased cardiovascular risk following PFAS exposure. https://doi.org/10.1289/EHP14339.
Authors
- Michael C. Petriello (ORCID: https://orcid.org/0000-0002-5583-8092)
- Todd A. Lydic (ORCID: https://orcid.org/0000-0003-3830-7406)
- Katherine Roth (ORCID: https://orcid.org/0000-0003-4826-3400)
- Johnna A. Birbeck
- Judy A. Westrick (ORCID: https://orcid.org/0000-0001-9112-5295)
- Zhao Yang (ORCID: https://orcid.org/0000-0002-4133-3130)
- Katherine Gurdziel (ORCID: https://orcid.org/0000-0002-3784-072X)
- Manisha Agarwal
Institutions
- Wayne State University (US)
- Michigan State University (US)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1289/ehp14339
- Citations
- 12
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 3.00
Funders
- Wayne State University
- National Institutes of Health