Effect of Genetic Risk on the Relationship Between rs-fMRI Complexity and Tau and Amyloid PET in Alzheimer’s Disease
Reduced functional magnetic resonance imaging (fMRI)-complexity in Alzheimer's disease (AD) progression has been demonstrated and found to be associated with tauopathy and cognition. However, association of fMRI-complexity with amyloid and influence of genetic risk (APOEɛ4) remain unknown. Here we investigate the association between fMRI-complexity, tau-PET, and amyloid-PET as well as influence of APOE genotype using multivariate generalized linear models. We show that fMRI-complexity has a strong association with tau but not amyloid deposition and that the presence of an APOEɛ4 allele enhances this effect. Thus fMRI-complexity provides a surrogate marker of impaired brain functionality in AD progression.
Authors
- Dilmini Wijesinghe (ORCID: https://orcid.org/0000-0002-2696-6781)
- Steven Cen (ORCID: https://orcid.org/0000-0002-7859-8909)
- Leon Aksman (ORCID: https://orcid.org/0000-0003-2342-0780)
- Kay Jann (ORCID: https://orcid.org/0000-0003-3574-0538)
- Kirsten M. Lynch (ORCID: https://orcid.org/0000-0003-3976-5783)
- Danny J.J. Wang (ORCID: https://orcid.org/0000-0002-0840-7062)
- John M. Ringman (ORCID: https://orcid.org/0000-0001-5429-0777)
- Ru Zhang (ORCID: https://orcid.org/0000-0001-8744-4525)
- M. Danda Vasconcelos Santos
Institutions
- University of Southern California (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3233/jad-240459
- Citations
- 5
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research
- National Institute on Aging