Impaired Skeletal Development by Disruption of Presenilin-1 in Pigs and Generation of Novel Pig Models for Alzheimer’s Disease
PSEN1 has a critical role for normal vertebral development and PSEN1 mutant pigs serves as novel resources to study Alzheimer's disease.
Authors
- Emily D. Reese
- Timothy J. Jarome (ORCID: https://orcid.org/0000-0001-9189-8992)
- Randall S. Prather (ORCID: https://orcid.org/0000-0002-6012-4035)
- Timothy A. Allen (ORCID: https://orcid.org/0000-0002-3512-9475)
- Kyungjun Uh (ORCID: https://orcid.org/0000-0001-8893-1034)
- Kaylynn Monarch
- Paula R. Chen (ORCID: https://orcid.org/0000-0003-4134-5235)
- Lee D. Spate
- Kiho Lee (ORCID: https://orcid.org/0000-0001-6151-6543)
- Melissa Samuel (ORCID: https://orcid.org/0000-0002-1416-7835)
- Katherine Rodriguez
- Sehwon Koh
- Junchul David Yoon
Institutions
- Agricultural Research Service (US)
- United States Department of Agriculture (US)
- Florida International University (US)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- University of Missouri (US)
- Virginia Tech (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-08-23
- DOI
- https://doi.org/10.3233/jad-231297
- Citations
- 3
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- University of Missouri
- National Synchrotron Radiation Research Center
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases